Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase
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چکیده
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Are Heart Muscle Irisin Levels and FNDC5 Gene Expression Regulated by Endurance and Resistance Exercises?
Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance training. Methods. Fifteen male rats (10-12 weeks old and 331.8&plu...
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Activation of the Hedgehog (Hh) signaling pathway has been implicated in a variety of malignancies including neuroblastoma. Expression of Gli1, a downstream effector of Hh, correlates with a favorable prognosis in patients with neuroblastoma. Moreover, Gli1 overexpression reduces mitotic index and induces transcription of genes involved in the differentiation of neuroblastoma cells; however, mu...
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A putative messenger RNA (mRNA) sequence, designated C8, that was up-regulated in Sertoli cells prepared from hypophysectomized rats treated with testosterone, was isolated from a Sertoli cell complementary DNA (cDNA) library. The coding region of C8 exhibited 99% identity with rat brain ecto-ATPase and expressed a 60-kilodalton protein following in vitro transcription/translation. Transfection...
متن کاملMultiple Cu-ATPase genes are differentially expressed and transcriptionally regulated by Cu exposure in sea bream, Sparus aurata.
Copper (Cu) is an essential metal, although in excess is highly toxic due to its redox properties and, therefore intracellular Cu homeostasis is a highly regulated process. Cu-ATPases are pivotal regulatory, proteins of intracellular and bodily Cu homeostasis. Two Cu-ATPases, ATP7A and ATP7B with distinct, functions are found in mammals and herein we report the structure and expression under Cu...
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We investigated the chromosomal organization and developmental regulation of soybean 8-conglycinin genes. The 8-conglycinin gene family contains at least 15 members divided into two major groups encoding 2.5-kilobase and 1.7-kilobase embryo mRNAs. 8-Conglycinin genes are clustered in severa1 DNA regions and are highly homologous along their entire lengths. The two groups differ by the presence ...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2012
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.2012.159